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Replaceable You: Adventures in Human Anatomy
Replaceable You: Adventures in Human Anatomy | Mary Roach
22 posts | 6 read | 11 to read
The body is the most complex machine in the world, and the only one for which you cannot get a replacement part from the manufacturer. For centuries, medicine has reached for what's available--sculpting noses from brass, borrowing skin from frogs and hearts from pigs, crafting eye parts from jet canopies and breasts from petroleum by-products. Today we're attempting to grow body parts from scratch using stem cells and 3D printers. How are we doing? Are we there yet?In Replaceable You, Mary Roach explores the remarkable advances and difficult questions prompted by the human body's failings. When and how does a person decide they'd be better off with a prosthetic than their existing limb? Can a donated heart be made to beat forever? Can an intestine provide a workable substitute for a vagina?Roach dives in with her characteristic verve and infectious wit. Her travels take her to the OR at a legendary burn unit in Boston, a "superclean" xeno-pigsty in China, and a stem cell "hair nursery" in the San Diego tech hub. She talks with researchers and surgeons, amputees and ostomates, printers of kidneys and designers of wearable organs. She spends time in a working iron lung from the 1950s, stays up all night with recovery techs as they disassemble and reassemble a tissue donor, and travels across Mongolia with the cataract surgeons of Orbis International.Irrepressible and accessible, Replaceable You immerses readers in the wondrous, improbable, and surreal quest to build a new you.
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review
monalyisha
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Pickpick

Not my favorite Mary Roach but that‘s because I‘m more interested (for better or worse) in topics like the afterlife, wildlife, & outer space than I am in care of the human body while we‘re alive. Wise? No! Yet true.

Still fascinating (though it made me grimace a few times & I‘ve got a pretty strong stomach).

I remain convinced that Mary Roach is THE coolest person. I hope she gets a personal pig so she can live & write for a very long time. 🐷

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Soubhiville
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Pickpick

Are you curious about replacement organs and transplants? Body science? Medical history? Mary Roach approaches all of this with her usual humor in this new release. I learned quite a bit as always.

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Lands

“People don‘t realize how dangerous anesthesia can be, said Jordan Newmark, who is the anesthesiologist I met. “I‘ve been saying for years, they should make a movie like Top Gun but about anesthesiology,” he said when we first spoke. At the time, this confused me. It was as though Jordan had access to some bizarro elevator-pitch app that randomly combined hit movies with medical specialties. Like Gladiator, but about urology. He was insistent:

Lands intubation is one of the riskiest maneuvers in modern medicine. “People get surgery Willy-nilly, like getting their hair cut. But it‘s frickin scary. No one knows.” 2w
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Lands

“Stoodley doesn‘t dwell on it. “There are two kinds of micro-biologists,” he said. “There are the ones who say, “Bacteria are everywhere! We‘ve got to sterilize everything!” His wife is one of those. “Then there‘s the ones who say, “Bacteria are everywhere! And yet we‘ve survived! “ That‘s Stoody. “I‘m very cavalier,” he said. I am too, though a little less so now. One thing I‘m funny about is drinking from Mason jars. You just know there‘s mouth-

Lands biofilm lurking between those hard-to-clean screw-top ridges.” 2w
28 likes1 comment
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keithmalek
Mehso-so
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Lands

“Certain surgeons kind of like thump their chest that they made such a big one,” Garcia is saying. He takes a last swallow of Chianti. “It‘s so stupid.” (In fairness to surgeons, trans men fairly commonly, Garcia says, request a neophallus larger than the average natal penis. But the extreme cases seem to have been the surgeons doing.) “

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Lands

“I find equally remarkable the inventiveness and confidence of surgeons who dream up operations like this one. Who looks at the human digestive tract and thinks, moist, tubular, stretchy…Might that make a reasonable vagina?”

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Lands

“Locanda Veneta is an old-school Italian restaurant in the shadows of the Cedars-Sinai urology building, in Los Angeles. It is quiet, softly lit, and a bit of a splurge. It‘s the kind of place you might take your date for a romantic meal, especially if your date is , as mine is, a urologist. I‘ve reserved table 12, a cozy corner two- top where most other patrons can‘t see or hear you, and the banquette is just long enough for two people to -

Lands squeeze in side by side. It‘s the table for canoodlers, or people having unrestricted conversation about surgically fashioning a vagina out of a colon. “ 2w
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keithmalek

The original Mr. Potato Head kit in fact had no potato. It was sold as a set of plastic body parts and accessories to be poked into an actual potato supplied by parents. After years of complaints--rotting potatoes in the playroom, children poking themselves and choking on tiny mustaches and pipes--Hasbro began including a plastic “potato body“ and accessories large enough to pass choke-tube tests.

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keithmalek

For reasons that remain a mystery, a heart needs a brain. When a person is declared brain-dead, their heart--along with their other organs--begins to fail around after twelve hours, even if the body is being oxygenated on a ventilator. The blood vessels lose tone, the capillaries start to leak, and within forty-eight hours its all over.

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keithmalek

With the 1914 discovery of the anticoagulent sodium nitrate and the pressing demands of world wars, public blood donation began to go mainstream. Whereupon the new challenge was human squeamishness. Up through the 1940s, donor centers would set up chairs alongside arm-sized holes cut into a wall-sized partition. Donors would slide their arm through a hole, making a donation without ever having to see the blood, the needle, or the...

keithmalek ...phlebotamist sitting on the other side. Blood bank glory holes! 3w
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keithmalek

Burn survivors can develop hypothermia in a 70 degree room. ICUs and ORs for survivors of major burns are often kept at 90 or even 105 degrees, nurses and surgeons sweating under their scrubs and sterile gowns.

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keithmalek

Between 13 and 25 percent of surgeons grapple with substance abuse at some point in their careers.

keithmalek In that case, remind me to never get surgery. 3w
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Lands

“The chilled heart sits in a bowl while the two surgeons work the tubes. With no blood pumping through, a heart is a pale, floppy thing, a far cry from the familiar red graphic of emojis and Valentines cards. This one, at the moment, reminds me of a skinless, boneless chicken breast. Drake holds a slice of the aorta and passes me a pair of surgical scissors so I can get a sense of how thick and rubbery it is. I would defy you to distinguish-

Lands (without tasting) a ring of aorta from a ring of calamari.” 3w
Ruthiella No thank you, Mary! 🤢😂 3w
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keithmalek

As far back as 1500 BC, in India, and extending through the Roman Empire and ninth century Ireland, nasal mutilation was a form of punishment. Because of the organ's visibility, sitting as it does in the middle of the face, nasal disfigurement served as both humiliation and a warning to the populace. Noses were hacked off for thievery, tax evasion, adultery, disloyalty. Bounties were placed on enemy noses. Entire towns denosed.

keithmalek (continued) Syphillis brought renewed demand. In its later stages, the disease can cause the bridge of the nose to deteriorate and collapse. 3w
Suet624 Dear god! That‘s disgusting. 3w
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keithmalek

Rhinoplasty was the original plastic surgery.

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keithmalek

For every step forward, three go nowhere. Progress doesn't march, it lurches.

review
Megabooks
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Mary continues to be the most delightful pop sci author I‘ve read! In this one, she takes a look at the people and technology around replacement or adapted body parts. She talks to experts in hair transplants and how they might provide a window in to developing other autologous organs. She looks at the challenges of 3D printing tissues. And hangs out with ostomy patients and folks with prostheses to learn more about how those affect their lives.

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Lands
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I‘m going to start this one right away. I‘m tempted to read “the ass man” chapter first. It‘s on surgical procedures. I‘ve noticed a real proliferation of buttocks enhancing leggings and work-out clothes especially in work-out videos. 🍑

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NotCool
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Pickpick

Mary Roach! I wasn‘t expecting a new Mary Roach book this fall and was very excited! Body horror! Science!

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Hooked_on_books
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I‘m happy to report Mary Roach‘s latest is a ton of fun! It‘s about human anatomy, specifically the parts we can or are trying to be able to replace. Think hair plugs, prostheses, organ transplant. I snort laughed in any number of places. Be aware this is not for the squeamish—she doesn‘t hold back on descriptions of surgical dissection.

ShyBookOwl I wish I could stomach Mary Roach lol her books always sound fascinating but triggering lol 1mo
Ruthiella I just heard about this book on This Podcast Will Kill You. 1mo
51 likes6 stack adds2 comments
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TieDyeDude
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ALA 2025 haul! My wife went for work, and I got a ticket for the last day for myself. We got to see Joe Hill speak and attended an Author Gala tea event that included Mary Roach, Sarah Penner, and Kiran Desai. Things were pretty well picked over by the last day, but I'm happy with what I got and it was a fun day with @WildAlaskaBibliophile

TheBookHippie Oh what a great haul!!!!! ♥️ 4mo
AmyG Sounds wonderful! 4mo
Amiable Sounds like you guys had a great trip! 4mo
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Eggs How fun! 4mo
AnnCrystal 👏🏼🤩👍🏼📚💫. 4mo
Gissy 📚📚🤩🎉🎉 4mo
65 likes6 comments