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My third Richard Powers, and the earliest and longest (675 pages) of his that I've read, this one had the least favourable effort to reward ratio. The plentiful, and lengthy, discussions of molecular genetics largely went over my head. (I didn't fare a whole lot better with the Bach.) The fact of someone's thinking to make this a major theme of their novel is strangely pleasing to me, but in practice reading it was hard work. Still a pick, though.